THE ROLE OF VITAMIN D AND ULTRAVIOLET RADIATION IN DEVELOPMENT OF ANATOMICAL-FUNCTIONAL CHANGES IN DIFFERENT SKELETAL PARTS AND THEIR IMPORTANCE FOR MOTOR ACTIVITY PROVISION 

Печать

Eliava G.G., Kasradze P.A., Mzhavanadze R.G., Balashvili M.I., Beridze K.M., Kvinikadze I.R., Topuria L.S., Topuria E.S.

Eliavа Giorgi Grigorjevich - doctor of biological sciences, Professor

DEPARTMENT OF PHARMACY,

 GEORGIAN TECHNICAL UNIVERSITY

Каsradzе Pavle Aleksandrovich - doctor of medicine, Head,

DEPARTMENT OF MEDICAL REHABILITATION AND SPORTS MEDICINE,

ACADEMICIAN N. KIPSHIDZE CENTRAL UNIVERSITY CLINIC

Mzhavanadze Rusudan Givievna - doctor of medicine, associate professor

Balashvili Mariam Iraklievna - doctor of biology, associate professor

DEPARTMENT OF ANATOMY, PHYSIOLOGY, BIOLOGY AND BIOCHEMISTRY,

Beridze Ketevan Muradovna - associate professor

FACULTY OF PHYSICAL MEDICINE AND REHABILITATION,

GEORGIAN STATE UNIVERSITY OF SPORTS

Kvinikadze Irma Revazovna - assistant professor

DEPARTMENT OF MEDICAL REHABILITATION AND SPORTS MEDICINE

TBILISI STATE MEDICAL UNIVERSITY

Topuria Lela Sergeevna - doctor of biology, Professor,

DEPARTMENT OF CHEMICAL AND BIOLOGICAL TECHNOLOGY,

Topuria Еkaterina Sergeevna – doctor of chemistry, associate professor,

DEPARTMENT OF CHEMISTRY,

GEORGIAN TECHNICAL UNIVERSITY,

TBILISI, GEORGIA

Abstract: human body is influenced by many exogenic and endogenic factors, which determine its motor activity and physical work capacity.

Vitamin D deficiency causes anatomic and functional changes in different parts of human skeleton, followed by change in biomechanics of movements and malfunction of visceral organs.

Vitamin D deficiency provokes calcium and phosphorus metabolic imbalance and disorder of neuromuscular conductivity, which has significant impact on adequate motor activity, can cause mineral density reduction in bones of different skeletal parts that may become a reason of fractures during vigorous physical exercises.

In addition to nutritional therapy, pharmaceutical treatment and kinesitherapy, the effect of small doses of ultraviolet rays is of significant importance. They not only promote vitamin D synthesis in the skin, but also induce sympathoadrenal system activation, which is of great importance for motor activity optimization. The above-mentioned measures facilitate reduction in fall and fracture risk and promote life quality improvement.

From the prevention viewpoint, in case of vigorous physical exercises it is recommended to determine a follow-up vitamin D level, especially if risk-factors are present. The mentioned above promotes timely delivery of drug therapy, use of kinesitherapy and physiotherapy, which will improve life quality and will maintain preservation of adequate physical work capacity.            

Keywords: D vitamin, calcium, phosphorus, ultraviolet radiation, physical work capacity.

РОЛЬ ВИТАМИНА D И УЛЬТРАФИОЛЕТОВОГО ИЗЛУЧЕНИЯ В РАЗВИТИИ АНАТОМО-ФУНКЦИОНАЛЬНЫХ ИЗМЕНЕНИЙ В РАЗЛИЧНЫХ ЧАСТЯХ СКЕЛЕТА И ИХ ЗНАЧЕНИЕ В ОБЕСПЕЧЕНИИ ДВИГАТЕЛЬНОЙ АКТИВНОСТИ

Элиава Г.Г., Касрадзе П.А., Мжаванадзе Р.Г., Балашвили М.И., Беридзе К.М., Квиникадзе И.Р., Топурия Л.С., Топурия Е.С.

Элиава Георгий Григорьевич - доктор биологических наук, профессор;

департамент фармации,

Грузинский технический университет

 Касрадзе Павел Александрович – доктор медицины, профессор, руководитель департамента;

департамент медицинской реабилитации и спортивной медицины,

Центральная университетская клиника им. академика Н. Кипшидзе

Мжаванадзе Русудан Гивиевна - доктор медицины, ассоциированный профессор;

Балашвили Мариам Ираклиевна - доктор биологии, ассоциированный профессор,

департамент анатомии, физиологии, биологии и биохимии,

Беридзе Кетеван Мурадовна - ассоциированный профессор,

Факультет физической медицины и реабилитации,

Грузинский государственный университет спорта

Квиникадзе Ирма Ревазовна - ассистент-профессор

департамент медицинской реабилитации и спортивной медицины

Тбилисского государственного медицинского университета

Топурия Лела Сергеевна - доктор биологии, профессор,

департамент химической и биологической технологии,

Топурия Екатерина Сергеевна – доктор химии, ассоциированный профессор,

департамент химии,

Грузинский технический университет,

г. Тбилиси, Грузия

Аннотация: на организм человека действует множество экзогенных и эндогенных факторов, которые определяют его двигательную активность и физическую работоспособность.

Дефицит витамина Д вызывает анатомо-функциональные изменения различных частей скелета человека, меняется биомеханика движений и нарушаются функции висцеральных органов.

Дефицит витамина Д вызывает нарушение обмена кальция и фосфора и нервно-мышечной проводимости, что оказывает значительное влияние на адекватную двигательную активность, может вызвать снижение минеральной плотности в костях различных частей скелета, что может стать причиной переломов во время интенсивных физических нагрузок.

Помимо лечебного питания, медикаментозного лечения и кинезотерапии важное значение имеет действие малых доз ультрафиолетовых лучей, которые, кроме того, что способствует синтезу витамина Д в коже, вызывает активацию симпатоадреналовой системы, что имеет большое значение в оптимизации двигательной активности. Вышеуказанные мероприятия способствуют уменьшению риска падений и переломов и повышению качества жизни.

С точки зрения превенции, при интенсивных физических нагрузках рекомендовано определение в динамике уровня витамина Д, особенно при наличии риск-факторов. Вышеуказанное поспособствует своевременному проведению медикаментозного лечения, кинезотерапии и физиотерапии, что улучшит качество жизни и будет способствовать сохранению адекватной физической работоспособности.

Ключевые слова: витамин Д, кальций, фосфор, ультрафиолетовое облучение, физическая работоспособность.           

References / Список литературы

  1. Eliava G.G. Principles of biomechanics. Teaching aid. Publishing house Technical University, Tbilisi, 2001, 136 (in Georgian).
  2. Eliava G.G., Mshvenieradze D.D., Mshvenieradze N.D. et Motor action optimization mechanisms among veterans of war. Clinical hospital for war veterans of Georgia. Transactions. Tbilisi, 2001, pp. 416-418. (in Georgian).
  3. Eliava G.G., Tsintsadze T.G., Natroshvili I.G., Sopromadze Z.G., Svanishvili T.R, Tataradze E.R., Sopromadze M.M. Osteoarthrosis and its pharmaco- and kinesitherapy. Teaching aid for students, residents of medical specialties and physicians. Georgian Technical University, Publishing house Georgika, Tbilisi, 2020, ISBN 978-9941-8-2181-3, 128 (in Georgian).
  4. Eliava G.G., Tsintsadze T.G., Kasradze P., Mzhavanadze R.G., Balashvili M.I. Osteoporosis and its pharmaco- and kinesitherapy. Teaching aid for students of medical, physical education and sports specialties, Publishing house Georgika, Tbilisi, 2021, ISBN 978-9941-8-3252-9, 172 p. (in Georgian).
  5. Eliava G.G., Balashvili M.I. Mzhavanadze R., Tabidze M.Sh., Buachidze T.Sh. Impact of ultraviolet irradiation on physical work capacity and feasibility of using for diseases treatment and prevention. Collection of works of the Conference dedicated to 85th anniversary of Tbilisi balneological resort. Tbilisi balneological resort. November 4, 2023, Georgia, ISBN 978-9941-8-6717-0 (in Georgian).
  6. Eloshvili N. Vitamins – risks and profit. Collection of works of the Conference dedicated to 85th anniversary of Tbilisi balneological resort. Tbilisi balneological resort. November 4, 2023, Georgia, ISBN 978-9941-8-6717-0 (in Georgian).
  7. Tskhadadze N. The role of physical activity for osteoporosis prevention and rehabilitation, Collection of works of the Conference dedicated to 85th anniversary of Tbilisi balneological resort. Tbilisi balneological resort. November 4, 2023, Georgia, ISBN 978-9941-8-6717-0 (in Georgian).
  8. Bakuradze A.N., Eliava G.G. Respiratory irritations of breathing passages and methodological guidelines for their application. Publishing house «Sabchota Sakartvelo (Soviet Georgia)», Tbilisi, 1987, 94 p. (in Russian)
  9. Smirnov A.V. Bone tissue mineral density in women with rheumatoid arthritis during post-menopause period. Modern rheumatology, №1, 2008, vol. 2, pp. 48-52. (in Russian).
  10. Sucianu St., Ionesku-Blaza V., Moange M. Clinic and treatment of rheumatic diseases. Medical publishing house. Bucharest, 1983, 627 p. (in mmm)
  11. Eliava G.G., Mzhavanadze R.G., Balashvili M.I. Peculiarities of bone system structure and their role in execution of various types of motions. Teaching aid for students of physical education and sports, and biomedical specialties, Publishing house Georgika, Tbilisi, 2019, ISBN 978-9941-8-1583-6, 132 p. (in Georgian).
  12. Adams J.S., Hewison M. Update in Vitamin D, The Journal of Clinical Endocrinology & Metabolism, 2010, Vol. 95, pp. 471-478.
  13. Als O.S., Gotfremson , Christiansen C. The effects of glucocorticoids on bone mass in rheumatoid arthritis patients: influence of menopausal state. Arthritis Rheum, 1985; 28:369-75.
  14. Bikle D. Vitamin D: Production, metabolism, and mechanisms of action, 2009, www.endotext.org/parathyroid3.
  15. Bouillon R., Carmeliet G., Verlinden L. et al. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice/Endocrine Reviews, 2008, v. 29(6), pp. 726-776.
  16. Heaney R.P. The importance of calcium intake for lifelong skeletal health// Calcified Tissue International, 2002, v. 70, pp. 70-73.
  17. Camus J.P. (Boala Paget), Rev. Prat. (Paris), 1971, 21, 3, 453-465.
  18. Eliava G., Kasradze P., Tsintsadze T., Topuria L., Tabidze M. Determination of biomechanical criteria of human motion and their significance for assessment of pathological state. Modern Aspects of Medical Rehabilitation, Prevention and Healthy Lifestyle. Collection of scientific articles of International Symposium dedicated to 75th Anniversary of Tbilisi balneological resort (now: Tbilisi Balneology Resort “Tbilisi-SPA” – National Centre of Health and Rehabilitation) and to the 15th anniversary of its full renaissance, Resort Sairme, 2014, 9-13 October, pp. 161-165.
  19. Eliava, P. Kasradze, R.Mzhavanadze, M. Balashvili, T. Buachidze, L. Topuria, E. Topuria. Osteoporosis and integrated approach to its treatment. International Collection of Scientific Articles “The Questions of Health Resort Managing, Physiotherapy and Rehabilitation”, Volume III, Tbilisi, TBR 2020. ISSN 2449-271X; website: www.nplg.gov.ge, pp. 52-56.
  20. Eliava G., Tsintsadze T., Kasradze P., Mzhavanadze R., Balashvili M., Buachidze T., Topuria L., Topuria E. Some aspects of osteoarthrosis spread prevention and treatment. LXXI International Correspondence Scientific and Practical Conference “International Scientific Review of the Problems and Prospects of Modern Science and Education”, Boston, USA, June 22-23, 2020). Publishing House “Problems of Science” DOI: 10.24411/2542-0798-2020-17102; ISBN 978-1-64655-055-5, pp. 97-99 [Google Scholar].
  21. Eliava G.G., Tsintsadze T.G., Kasradze P.A., Mzhavanadze R.G., Balashvili M.I., Topuria L.S., Topuria E.S. The role of anatomico-physiological peculiarities in pathogenetic mechanisms development. LXX International Correspondence Scientific and Practical Conference: “European Research: Innovation in Science, Education and Technology”, March 10-11, 2021, London UK. Publishing House “Problems of Science” ISBN 978-1-64655-088-3, pp. 43-47 [Google Scholar].
  22. Eliava G., Jashi M., Kasradze P., Tsintsadze T., Topuria L. Comparative analysis of some indicators and statistical assessment methods of physical development and their importance when conducting rehabilitation measures. International Collection of Scientific Articles “The Questions of Health Resort, Managing, Physiotherapy and Rehabilitation”, Vol. II, Tbilisi, 2018, pp. 60-64 [Google Scholar].
  23. Eliava G., Kasradze P., Tsintsadze T., Svanishvili T., Topuria L. Some issues of rehabilitation measures in case of osteogenesis mechanisms disturbance. International Collection of Scientific Articles “The Questions of Health Resort, Managing, Physiotherapy and Rehabilitation”, Vol. II, Tbilisi, 2018, pp. 65-70.
  24. Eliava G.G., Tsintsadze T.G., Kasradze P.A., Mzhavanadze R.G., Balashvili M.I., Topuria L.S., Topuria E.S. The role of anatomico-physiological peculiarities in pathogenetic mechanisms development. LXX International Correspondence Scientific and Practical Conference: “European Research: Innovation in Science, Education and Technology”, March 10-11, 2021, London UK. Publishing House “Problems of Science” ISBN 978-1-64655-088-3, pp. 43-47 [Google Scholar].
  25. Eliava G.G., Isakadze A.L., Svanishvili T.R., Tsintsadze T.G., Topuria L.S. Composition structure of bone tissue and its change during physical load and formation of pathological state. Materials of the X International Scientific and Practical Conference, “Prospects of World Science – 2014”, July 30-August 7, 2014, vol. 7, Medicine, Biological sciences, Chemistry and chemical technology, Ecology. Sheffield. Science and Education Ltd., England&Wales, pp. 11-15.
  26. Eliava G.G., Tsintsadze G.G., Natroshvili I.G., Svanishvili T.R Kvinikadze I.R., Gogokhia N.G., Topuria L.S., Topuria E.S. Importance of Laser Therapy in Homeostasis Preservation System and Psychoemotional Structures Activity. XC international correspondence scientific and practical conference „International Scientific Review of the Problems and Prospects of Modern Science and Education» (Collection of scientific articles) (Boston. USA. August 30-31, 2023), pp. 44-50 [Google Scholar].
  27. Eliava G.G., Tsintsadze T.G., Mzhavanadze R.G., Balashvili M.I., Topuria L.S., Topuria E.S. Morphofunctional Changes in Skeleton Bones during Paget’s Disease and their Prevention Issues. International scientific review of problems and prospects of modern science and education/ Collection of scientific articles. XCV international correspondence scientific and practical conference: Boston. USA, April 14-15, 2024 [Google Scholar].
  28. Eliava G.G., Kasradze P.A., Balashvili M.I., Mzhavanadze R.G., Kvinikadze I.R., Topuria L.S., Topuria E.S. Changes in Lower Extremities Venous System Anatomy Structure and Peculiarities of Different Type Compression Carried out for Curative Purposes. International scientific review of problems and prospects of modern science and education/ Collection of scientific articles. XCVIII international correspondence scientific and practical conference: Boston. USA, October 08-09, 2024[Google Scholar].
  29. Eliava, P. Kasradze, I. Natroshvili, Z. Sopromadze, T. Svanishvili, E. Tataradze, I. Kvinikadze, L. Topuria. Medicinal agents, kinezi- and physiotherapy during chronic venous insufficiency. Teaching aid for students of medical specialties. Publishing house Georgika, Tbilisi, 2023, pp. 1-196 (in Georgian).
  30. Bogolyubov V.M. Physiotherapy and balneotherapy (2nd book). М., Binom, 2008 (in Russian).
  31. Lutoshkina М.G. Physical factors in chronic venous insufficiency rehabilitation. Physiotherapy, balneotherapy and М., Publishing house «Medicine», 2, 2014, 40-47, ISSN: 1681-3456 (in Russian).
  32. Ulashchik V.S., Lukomsky I.V. General Physiotherapy. Minsk, 2003 (in Russian).
  33. Gregory W. Hartley, Kathryn E. Roach, Robert W. Nithman, Sherri R. Betz, Carleen Lind- sey, Robyn K. Fuchs, and Keith G. Avin. J Geriatr Phys Ther. 2022 Apr; 44(2) Physical Therapist Management of Patients With Suspected or Confirmed Osteoporosis: A Clinical Practice Guideline From the Academy of Geriatric Physical Therapy.
  34. Royal osteoporosis society. strong, steady and straight. Guid-2019. An Expert Consensus Statement on physical activity and exercise for osteoporosis. https://strwebstgmedia.blob. core.windows.net/media/1hsfzfe3/consensus-statement-strong-steady-and-straight-web-march-2019.pdf
  35. Kemmler W, Häberle L, Von Stengel S. Effects of exercise on fracture reduction in older adults: a systematic review and meta-analysis. Osteoporos Int. 2013;24(7):1937-1950. doi:10.1007/ s00198-012-2248-7 [PubMed] [Google Scholar]
  36. Lequesne M., Forest M., Perez C., Narboni C., De Sêze S. Les coxopathies pagetiques. Etude radio-clinique et anatomopathologique, Rev. Rhum., 1975, 42, 10, 545-550.
  37. Manigand G. (Studiul clinic, biologic, radiologic si terapeutic al bolii Paget) Rev. Prat. (Paris), 1969, 19, 7, 863-880.
  38. Simon L., Blotman F., Seignalet J., Claustre J. Etiologie de la maladies osseuse de Paget a oaselor. Rev. Rhum., 1975, 42, 10, 535-544.
  39. Simon L., Serre H. La maladie osseuse de Paget (Textes rêunis) – Premier colloque de pathologie locomotrice, Montpellier med., 1974.
  40. Towheed T.E., Brouillard D., Yendt E. et al. Osteoporosis in rheumatoid arthritis: findings in the metacarpal spine and hip and a study of the determinations of both localized and generalized osteopenia. J. Rheumatol., 1995, 22:440-3.
  41. Lesnyak О.М., Nikitinskaya О.А., Toroptsova N.V. et al. Prevention, diagnostics and treatment of vitamin D and calcium deficiency among adult population of Russia and patients with osteoporosis (following the prepared clinical recommendations). Scientific and practical rheumatology. 2015;53(4):403-408 (in Russian).
  42. Karonova Т.L. Vitamin D deficiency: from recommendations to practical actions. Lecture in НМО system (18.10.2018) (in Russian)
  43. Pilz S., Zittermann A., Trummer C., et al. Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect. 2019;8(2):R27-R43.
  44. Pigarova Е.А., Rozhinskaya L.Ya., Belaya Zh.Е. et al. Vitamin D deficiency among adults: diagnostics, treatment and prevention. Clinical guidelines of the Association of Endocrinologists. Moscow. 2015. 75 p. (in Russian)
  45. Holick M.F., Binkley N.C., Bischoff-Ferrari H .A., et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Clin Endocrinol Metab. 2011 Jul; 96(7):1911-30.
  46. Gromova О.А., Torshin I.Yu., Zakharova I.N., Spirichev V.B., Limanova О.А., Borovik Т.E., Yatsyk G.V. On vitamin D dosage for children and adolescents. Problems of Modern Pediatrics. 2015;14(1):38-47 (in Russian)
  47. Karonova Т.L. Osteoporosis: modern approaches to diagnostics, prevention and treatment. Lecture in НМО system (30.05.2018) (in Russian)
  48. Zaprudnov А.М., Grigorjev К.I. Osteoporosis: modern approaches to diagnostics, prevention and treatment. Periodicals of «RMJ». № 1997 (in Russian)
  49. Marcinowska-Suchowierska E., Kupisz-Urbańska M., Łukaszkiewicz J., et al. Vitamin D toxicity - a clinical perspective. Frontiers in Endocrinology 2018. 9: 550
  50. Kannan S. and Lim H.W. (2014), Photoprotection and vitamin D. Photodermatol. Photoimmunol. Photomed., 30: 137-145.

Ссылка для цитирования данной статьи

scientificjournal-copyright    

Тип лицензии на данную статью – CC BY 4.0. Это значит, что Вы можете свободно цитировать данную статью на любом носителе и в любом формате при указании авторства.

Eliava G.G., Kasradze P.A., Mzhavanadze R.G., Balashvili M.I., Beridze K.M., Kvinikadze I.R., Topuria L.S., Topuria E.S. THE ROLE OF VITAMIN D AND ULTRAVIOLET RADIATION IN DEVELOPMENT OF ANATOMICAL-FUNCTIONAL CHANGES IN DIFFERENT SKELETAL PARTS AND THEIR IMPORTANCE FOR MOTOR ACTIVITY PROVISION  // Вестник науки и образования №3 (158), 2025 [Электронный ресурс]. 

Eliava G.G., Kasradze P.A., Mzhavanadze R.G., Balashvili M.I., Beridze K.M., Kvinikadze I.R., Topuria L.S., Topuria E.S. THE ROLE OF VITAMIN D AND ULTRAVIOLET RADIATION IN DEVELOPMENT OF ANATOMICAL-FUNCTIONAL CHANGES IN DIFFERENT SKELETAL PARTS AND THEIR IMPORTANCE FOR MOTOR ACTIVITY PROVISION // Вестник науки и образования №3 (158), 2025, C. {см. журнал}.

 scientificjournal

 
Метки: different • activity • motor • importance • their • parts • skeletal • functional • changes • anatomical • development • radiation • ultraviolet • vitamin • provision 

Поделитесь данной статьей, повысьте свой научный статус в социальных сетях

       Tweet   
  
  

Похожие статьи:

Информация о материале
Категория: 14.00.00 МЕДИЦИНСКИЕ НАУКИ
Просмотров: 72